Cluster of differentiation 44 (CD44) is a glycoprotein receptor for hyaluronic acid, which plays a fundamental role in cellular adhesion, stromal binding, migration, and cell-cell interactions. Studies have suggested that the CD44-hyaluronate interaction is central to tumor invasiveness. Positive staining with Anti-CD44 is implicated in a multitude of different cancer types, including breast, prostatic, renal cell, colonic, hepatocellular, and genitourinary carcinomas, as well as Non-Hodgkin’s Lymphoma, metastatic melanoma, gastric cancer, and some soft tissue tumors. It has also been demonstrated that there is a positive correlation between tumor progression and increased expression of CD44v, a high molecular weight CD44 isoform that has been described in epithelial cells. Given the expression of CD44 in a wide range of cancers, the most practical application of CD44 immunostaining is its use in discriminating between urothelial transitional cell carcinoma in situ from non-neoplastic changes in the urothelium.

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Image Variation SKU Price Quantity Add To Cart
CD44-IHC044-Breast-Cancer 0.1ml IHC044-100 208.00
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CD44-IHC044-Breast-Cancer 1ml IHC044-1 858.00
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CD44-IHC044-Breast-Cancer Positive Control 3 slides IHC044-PC 770.00
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CE-IVD registered and supplied as a concentrate.   


Clone IHC044
Source Mouse Monoclonal
Positive Control Benign Urothelium
Dilution Range 1:100 – 1:200


    1. Li F, et al. Cell Res. 2007; 17:3-14.
    2. Ponta H, et al. Nat Rev Mol Cell Biol. 2003; 4:33-45.

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0.1ml, 1ml, Positive Control 3 slides


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