MDR3
MDR3
₪971.00 – ₪5,096.00
Multidrug Resistance 3 (MDR3), also known as ATP Binding Cassette Subfamily B Member 4 (ABCB4), is a membrane-associated protein belonging to the superfamily of ATP-binding cassette transporters. MDR3 is an energy-dependent phospholipid efflux translocator that mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte, and also acts as a positive regulator of biliary lipid secretion. Defects in MDR3 are associated with progressive familial intrahepatic cholestasis type 3 and gallbladder disease type 1. Co-overexpression of MDR3 and MRP1 has been documented as correlating with blastemal subtype and high-risk prognosis of Wilms’ tumor patients.
| Image | Variation | SKU | Price | Quantity | Add To Cart |
|---|---|---|---|---|---|
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0.1ml | IHC621-100 | ₪971.00 | |
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1ml | IHC621-1 | ₪5,096.00 | |
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Positive Control 3 Slides | IHC621-PC | ₪1,323.00 | |
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Description
CE-IVD registered and supplied as a concentrate.
Specifications
| Clone | IHC621 |
| Source | Mouse Monoclonal |
| Positive Control | Adrenal Cortex |
| Dilution Range | 1:100 – 1:200 |
References
- Hontecillas-Prieto L, et al. Oncotarget. 2017; 8:11173-86.
- van Helvoort A, et al. Cell. 1996; 87:507-17.
- Morita SY, et al. Hepatology. 2007; 46:188-99.
- Crawford AR, et al. J Clin Invest. 1997; 100:2562-7.
- de Vree JML, et al. Proc Natl Acad Sci U S A. 1998; 95.
- Rosmorduc O, et al. Gastroenterology. 2001; 120:1459-67.
Additional information
| Units | 0.1ml, 1ml, Positive Control 3 slides |
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