MDR3

MDR3

971.005,096.00

Multidrug Resistance 3 (MDR3), also known as ATP Binding Cassette Subfamily B Member 4 (ABCB4), is a membrane-associated protein belonging to the superfamily of ATP-binding cassette transporters. MDR3 is an energy-dependent phospholipid efflux translocator that mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte, and also acts as a positive regulator of biliary lipid secretion. Defects in MDR3 are associated with progressive familial intrahepatic cholestasis type 3 and gallbladder disease type 1. Co-overexpression of MDR3 and MRP1 has been documented as correlating with blastemal subtype and high-risk prognosis of Wilms’ tumor patients.
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Image Variation SKU Price Quantity Add To Cart
0.1ml IHC621-100 971.00
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1ml IHC621-1 5,096.00
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Positive Control 3 Slides IHC621-PC 1,323.00
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Description

CE-IVD registered and supplied as a concentrate. 

Specifications

Clone IHC621
Source Mouse Monoclonal
Positive Control Adrenal Cortex
Dilution Range 1:100 – 1:200

References

  1. Hontecillas-Prieto L, et al. Oncotarget. 2017; 8:11173-86.
  2. van Helvoort A, et al. Cell. 1996; 87:507-17.
  3. Morita SY, et al. Hepatology. 2007; 46:188-99.
  4. Crawford AR, et al. J Clin Invest. 1997; 100:2562-7.
  5. de Vree JML, et al. Proc Natl Acad Sci U S A. 1998; 95.
  6. Rosmorduc O, et al. Gastroenterology. 2001; 120:1459-67.

Additional information

Units

0.1ml, 1ml, Positive Control 3 slides

Documents

Safety Data Sheet

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