MLH1
MLH1
₪301.00 – ₪1,326.00
MutL Homolog 1 (MLH1) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, as the MLH1 gene is frequently mutated in patients with this cancer. Studies have shown MLH1 to be deficient in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MLH1 is optimized when paired in an IHC panel with MSH6, MSH2, and PMS2. Anti-MLH1 is useful in the detection of MLH1 in a number of normal and neoplastic tissues, and for identifying a loss of MLH1 in tumors that are microsatellite-unstable.
| Image | Variation | SKU | Price | Quantity | Add To Cart |
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0.1ml | IHC409-100 | ₪301.00 | |
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1ml | IHC409-1 | ₪1,326.00 | |
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Positive Control | IHC409-PC | ₪770.00 | |
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Description
CE-IVD registered and supplied as a concentrate.
Specifications
| Clone | IHC409 |
| Source | Mouse Monoclonal |
| Positive Control | Colon, Colon Carcinoma |
| Dilution Range | 1:100 – 1:200 |
References
- Pal T, et al. Cancer. 2008; 113:733-42.
- Wright CL, et al. Am J Surg Pathol. 2003; 27:1393-1406.
- Brueckl WM, et al. Anticancer Res. 2003: 23:1773-8.
- Rigau V, et al. Arch Pathol Lab Med. 2003; 127:694-700.
- Renkonen E, et al. J Clin Oncol. 2003; 21:3629-37.
- Hoedema R, et al. Am Surg. 2003; 69:387-92.
- Christensen M, et al. Cancer. 2002; 95:2422-30.
- Wahlberg SS, et al. Cancer Res. 2002: 62:3485-92.
- Lanza G, et al. Mod Pathol. 2002; 15:741-9.
Additional information
| Unit | 0.1ml, 1ml, Positive Control |
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