Programmed Death-Ligand 1 (PD-L1), also known as CD274 or B7 Homolog 1 (B7-H1), is a transmembrane protein involved in suppressing the immune system and rendering tumor cells resistant to CD8+ T cell-mediated lysis through binding of the Programmed Death-1 (PD-1) receptor. Overexpression of PD-L1 may allow cancer cells to evade the actions of the host immune system. In renal cell carcinoma, upregulation of PD-L1 has been linked to increased tumor aggressiveness and risk of death, and, in ovarian cancer, higher expression of this protein has lead to significantly poorer prognosis. PD-L1 has also been linked to systemic lupus erythematosus and cutaneous melanoma. When considered in adjunct with CD8+ tumor-infiltrating lymphocyte density, expression levels of PD-L1 may be a useful predictor of multiple cancer types, including stage III non-small cell lung cancer, hormone receptor negative breast cancer, and sentinel lymph node melanoma.

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Image Variation SKU Price Quantity Add To Cart
PD-L1-IHC411-Lung-20X 0.1ml IHC411-100 231.00
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PD-L1-IHC411-Lung-20X 1ml IHC411-1 1,196.00
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PD-L1-IHC411-Lung-20X Positive Control IHC411-PC 722.00
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CE-IVD registered and supplied as a concentrate.


Clone IHC411
Source Rabbit Monoclonal
Positive Control Tonsil, Lung Adenocarcinoma
Dilution Range 1:100 – 1:200


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  2. Tokito T, et al. Eur J Cancer. 2016; 55:7-14.
  3. Park IH, et al. Clin Breast Cancer. 2016; 16:51-8.
  4. Kakavand H, et al. Mod Pathol. 2015; 28: 1535-44.
  5. Xia B, et al. Immunotherapy. 2016; 8:279-98.
  6. Patel SP, et al. Mol Cancer Ther. 2015; 14:847-56.
  7. Singh BP, et al. Cancers (Basel). 2016; 8.
  8. Chemnitz JM, et al. J Immunol. 2004; 173:945–54.
  9. Thompson RH, et al. Proc Natl Acad Sci USA. 2004; 101:17174–9.
  10. Hamanishi J, et al. Proc Natl Acad Sci USA. 2007; 104:3360–5.
  11. Mozaffarian N, et al. Rheumatology, 2008; 47:1335–41.

Additional information


0.1ml, 1ml, Positive Control


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