PMS2

PMS2

532.002,600.00

Postmeiotic Segregation Increased 2 (PMS2) is a DNA repair protein involved in mismatch repair. Mutations and deficiencies in the PMS2 gene have been linked to microsatellite instability, and malignancies such as hereditary nonpolyposis colorectal cancer and endometrial cancer. Expression levels of the PMS2 protein may be useful as a screening tool for Lynch syndrome after a colorectal cancer diagnosis. Anti-PMS2 is recommended to be used as part of a panel along with antibodies against MLH1, MSH2, and MSH6.

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Image Variation SKU Price Quantity Add To Cart
PMS2-IHC412-Duodenum 0.1ml IHC412-100 532.00
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PMS2-IHC412-Duodenum 1ml IHC412-1 2,600.00
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PMS2-IHC412-Duodenum Positive Control IHC412-PC 770.00
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Description

CE-IVD registered and supplied as a concentrate.   

Specifications

Clone IHC412
Source Mouse Monoclonal
Positive Control Colon
Dilution Range 1:100 – 1:200

References

  1. Cohn DE, et al. Int J Gynecol Cancer. 2008; 18:136-40.
  2. Modica I, et al. Am J Surg Pathol. 2007; 31:744-51.
  3. Sordet C, et al. Joint Bone Spine. 2006; 73:646-54.
  4. Balogh GA, et al. Int J Mol Med. 2006; 18:853-7.
  5. Halvarsson B, et al. Fam Cancer. 2006; 5:353-8.
  6. Gologan A, et al. Clin Lab Med. 2005; 25:179-96.
  7. Lagerstedt Robinson K, et al. J Natl Cancer Inst. 2007; 99:291-9.
  8. Hendriks YM, et al. Gastroenterology. 2006; 130:312-22.
  9. Truninger K, et al. Gastroenterology. 2005; 128:1160-71.
  10. Hampel H, et al. N Engl J Med. 2005; 352:1851-60.
  11. Warusavitarne J, et al. Int J Colorectal Dis. 2007; 22:739-48.
  12. Gill S, et al. Clin Cancer Res. 2005; 11:6466-71.
  13. Modica I, et al. Am J Surg Pathol. 2007; 31:744-51.
  14. Shia J, et al. Am J Surg Pathol. 2009; 33:1639-45.
  15. Kets CM, et al. Mod Pathol. 2006; 19:1624-30.

Additional information

Unit

0.1ml, 1ml, Positive Control

Documents

Instructions for Use

Safety Data Sheet

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